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Codeine has actually been described to point out no proof of carcinogenicity or mutagenicity in a variety of take a look at systems, including the micronucleus and sperm abnormality assays along with the Salmonella assay. Promethazine was nonmutagenic in the Salmonella exam system of Ames.benzhydrocodone/acetaminophen and promethazine both of those